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Altogether, our data deliver proof for that opportunity of mixing CX-5461 and PARPi for enhancing the cure of HR-deficient HGSOC. We reveal that CX-5461 improves the synthetic lethal interaction of PARPi with HRD and clearly present that CX-5461 has a different system of action to PARPi. Importantly, we characterized BRCA-mutated and MYC targets ge

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